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Dr. Lingling Chen

Professor, Indiana University Bloomington

Helen Hay Postdoctoral Fellow, Protein Crystallography, Yale University, 1997-2000

Ph.D., Chemistry, Stanford University, 1996

B.S., Physical Chemistry, Xiamen University, 1988

Structure, Function and Mechanism of Molecular Chaperone Hsp60

We are interested in structure and function of proteins involved in important biological processes that are related to human diseases or microbial infections. Our research proteins include those of molecular chaperone, transcription factor, and microbial effector that are important in protein quality control, signal transduction and microbial-host interaction, respectively. To investigate how proteins function at the molecular level, we apply a range of molecular biology, biochemical, and particularly structural methods of X-ray crystallography and cryogenic electron microscopy (Cryo EM).

We currently focus on molecular chaperone Hsp60. Hsp60 is essential for cellular viability, and it is highly conserved among three kingdoms of life. The main function of Hsp60 is, together with its cochaperone Hsp10, to mediate folding of cellular proteins. One of our projects is to investigate the mechanism of human mitochondrial mHsp60-mHsp10. Since mHsp60 is associated with various human health conditions, it has been proposed as possible drug targets and biomarkers. To provide structural basis for mechanistic understanding and drug targeting, we are determining structures of mHsp60-mHsp10 using Cryo EM.
Contact us:

Laboratory:

  • Location: Simon Hall MSB1 Room 301
  • Phone: (812) 856-0239
  • Fax (Simon Hall): (812) 856-5710

Dr. Chen's Office:

We are constantly looking for highly motivated graduate and undergraduate students who are interested in biomedical research. If you are interested, contact Dr. Chen at linchen@indiana.edu. Please include your resume and class schedule.

Copyright � Chen Research Group, Department of Molecular and Cellular Biochemistry, Indiana University
Maintained by Adhitya Balaji (last updated May 23, 2020) Back to previous page